Effect of Fluoxetine on the Induction of Long-term Potentiation in Rat Frontal Cortex
The Korean Journal of Physiology and Pharmacology
; : 295-300, 2004.
Article
в En
| WPRIM
| ID: wpr-727786
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WPRO
ABSTRACT
Serotonin (5-hydroxytroptamine, 5-HT) has been shown to affect the induction of long-term potentiation (LTP) in the cortex such as the hippocampus, the visual cortex and the prefrontal cortex. Fluoxetine, as a selective serotonin reuptake inhibitor, is used in the management of a wide variety of psychological diseases. To study the effect of fluoxetine on the induction of LTP, we recorded the field potential in layer II/III of the frontal cortex from 3-wk-old. LTP was induced in horizontal input by theta burst stimulation (TBS). TBS with two-folds intensity of the test stimulation induced LTP, which was blocked by application of D-AP5 (50microM), an NMDA receptor antagonist. Whereas bath application of 5-HT (10microM) inhibited the induction of LTP, treatment with the 5-HT depleting agent, para-chloroamphetamine (PCA, 10microM), for 2hr did not affect the induction of LTP. Bath application of fluoxetine (1, 3, and 10microM) suppressed the induction of LTP in concentration-dependent manner, however, fluoxetine did not inhibit the induction of LTP in 5-HT-depleted slices. These results indicate that fluoxetine may inhibit the induction of LTP by modulating serotonergic mechanism in the rat frontal cortex.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
P-Chloroamphetamine
/
Baths
/
Visual Cortex
/
Serotonin
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Fluoxetine
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N-Methylaspartate
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Prefrontal Cortex
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Long-Term Potentiation
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Hippocampus
Пределы темы:
Animals
Язык:
En
Журнал:
The Korean Journal of Physiology and Pharmacology
Год:
2004
Тип:
Article