A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages
Immune Network
; : 232-240, 2015.
Article
в En
| WPRIM
| ID: wpr-73367
Ответственная библиотека:
WPRO
ABSTRACT
The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Computer Simulation
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Immunoglobulins
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Hematopoietic Stem Cells
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Monocytes
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Macrophages, Peritoneal
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Computational Biology
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Myeloid Cells
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Cytoplasm
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Adaptive Immunity
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Macrophages
Пределы темы:
Humans
Язык:
En
Журнал:
Immune Network
Год:
2015
Тип:
Article