Detection of PD4, CD44, PCNA protein and its clinical significance in human laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 817-819, 2010.
Article
в Zh
| WPRIM
| ID: wpr-747488
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE@#To study the expression of PD4, CD44 and PCNA proteins in laryngeal carcinoma and their relationships with the pathogenesis, development and prognosis of laryngeal carcinoma.@*METHOD@#Immunohistochemistry was used to study 140 cases of laryngeal carcinoma tissues, 25 cases of precarcinoma tissues, 36 cases of vocal cord polyps and 13 cases of normal tissues adjacent to laryngeal carcinoma.@*RESULT@#1. The positive rates of PD4, CD44 and PCNA were 45.71% (64/140), 64.29% (90/140) and 77.86% (109/140) in laryngeal carcinoma, which were much higher than in non-carcinoma tissues (P < 0.01). 2. The third and fourth stages laryngeal carcinoma express stronger PD4 and CD44 than those of the first and second stages. Laryngeal carcinoma with cervical metastasis had higher expression than those without cervical metastasis. To 3 and 5 years' survival, PD4, CD44 and PCNA positive cases had lower chance than those negative cases(P < 0.01 or 0.05). 3. The over all positive rate of PD4, CD44 and PCNA was 27.86% (39/140) in laryngeal carcinoma tissues and 5.41% (4/74) in non-carcinoma tissues.@*CONCLUSION@#The high expression of PD4, CD44 and PCNA proteins maybe closely related to the pathogenesis, development and prognosis of laryngeal carcinoma.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pathology
/
Prognosis
/
Laryngeal Neoplasms
/
RNA-Binding Proteins
/
Proliferating Cell Nuclear Antigen
/
Hyaluronan Receptors
/
Apoptosis Regulatory Proteins
/
Larynx
/
Metabolism
/
Neoplasm Staging
Тип исследования:
Diagnostic_studies
/
Prognostic_studies
Пределы темы:
Adult
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Aged
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Aged80
/
Female
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Humans
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Male
Язык:
Zh
Журнал:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Год:
2010
Тип:
Article