Advanced research of lipopolysaccharide in sepsis / 中国小儿急救医学

ABSTRACT

Sepsis is a common clinical critical illness and causing serious public health problem worldwide. Lipopolysaccharide(LPS) release from the cytoderm of Gram-negative bacteria and is a pivotal initiating factor in the development of sepsis,which can induce pathological processes such as inflammation, coagulopathy and immunosuppression. Therefore,the research progress in LPS-related region is of great sig-nificance for understanding the pathogenesis of sepsis and developing new diagnostic and therapeutic methods for sepsis. This review summarized the related research progress of LPS and sepsis based on the recent litera-tures.