Effect of celecoxib and anti-osteogenic tablets on urinary hydroxyproline and C-terminal telopeptide of collagen type Ⅱ concentrations among adult Kaschin-Beck disease patients in Qinghai Province / 中华地方病学杂志

ABSTRACT

Objective To find changes of urinary biomarkers of hydroxyproline (HYP) and C-terminal telopeptide of collagen type Ⅱ (CTX-Ⅱ) after celecoxib and anti-osteogenic tablets treatment among adult Kaschin-Beck disease (KBD) patients in Qinghai Province,and provide the scientific data for treatment effect of adult KBD.Methods According to the "Diagnosis of Kaschin-Beck Disease" (WS/T 207-2010),120 cases KBD patients and 89 cases healthy control were divided into three groups,including drug treatment group,non-drug therapy group and control group.The drug treatment group was taken celecoxib (200 mg/pill,1 pill/day,1 time/day) and anti-osteogenic tablets (0.4 g/pill,4 pills/time,2 times/day) for 6 month.The urine samples of these persons were detected with the method of enzyme linked immunosorbent assay (ELISA) for analyzing HYP and CTX-Ⅱ.The results were corrected by creatinine (Cr).Results There were 54 cases of KBD patients (24 males,30 females) in drug treatment group with average age of (47.51 ± 12.30) years old;there were 66 cases of KBD patients (31 males,35 females) in non-drug therapy group with average age of (46.85 ± 13.57) years old;and there were 89 healthy people (41 males,48 females) in control group with average age of (48.75 ± 13.92) years old.By comparing the three groups,there were no statistical significant differences in gender (x2 =0.820,P ＞ 0.05) and ages (F =0.379,P ＞ 0.05).Medians of urinary HYP contents among drug treatment group,non-drug therapy group and control group were 62.47,106.04,65.80 μg/μmol·Cr,respectively,and the difference was statistically significant (Z =12.114,P ＜ 0.01);medians of urinary CTX-Ⅱ contents among drug treatment group,non-drug therapy group and control group were 555.23,702.92,495.54 ng/μ mol· Cr,respectively,and the difference was statistically significant (Z =20.454,P ＜ 0.01).Conclusion Levels of HYP and CTX-Ⅱ among adult KBD patients have changed after treatment with celecoxib and anti-osteogenic tablets,and can be used to determine the effect of treatment.