Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells
International Journal of Oral Biology
; : 50-54, 2019.
Article
в En
| WPRIM
| ID: wpr-764038
Ответственная библиотека:
WPRO
ABSTRACT
Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial muscle contraction, salivary secretion, and tooth development. However, knowledge regarding physiological crosstalk between melatonin and nAChRs is limited. In the present study, the melatonin-mediated modulation of nAChR functions using bovine adrenal chromaffin cells, a representative model for the study of nAChRs, was investigated. Melatonin inhibited the nicotinic agonist dimethylphenylpiperazinium (DMPP) iodide-induced cytosolic free Ca²⁺ concentration ([Ca²⁺](i)) increase and norepinephrine secretion in a concentration-dependent manner. The inhibitory effect of melatonin on the DMPP-induced [Ca²⁺](i) increase was observed when the melatonin treatment was performed simultaneously with DMPP. The results indicate that melatonin inhibits nAChR functions in both peripheral and central nervous systems.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Tooth
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Norepinephrine
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Central Nervous System
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Receptors, Nicotinic
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Circadian Rhythm
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Nicotinic Agonists
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Neurotransmitter Agents
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Chromaffin Cells
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Calcium Signaling
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Cytosol
Язык:
En
Журнал:
International Journal of Oral Biology
Год:
2019
Тип:
Article