Bone Regeneration Using Block-type Deproteinized Porcine Bone Mineral with Collagen Membrane Using 3,4-Dihydroxyphenylalanine as Bone Adhesive
Journal of Korean Dental Science
; : 43-56, 2018.
Article
в En
| WPRIM
| ID: wpr-764787
Ответственная библиотека:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to assess the adhesiveness and cytotoxicity of 3, 4-dihydroxyphenylalanine (DOPA), and to evaluate the role of collagen membrane with DOPA in the guided bone regeneration. MATERIALS ANDMETHODS:
Peel resistance and cell cytotoxicity test were performed. Four defect types in nine rabbit calvaria were randomly allocated i) control, ii) membrane, iii) deproteinized porcine bone mineral (DPBM) covered by membrane with DOPA, and iv) DPBM covered by membrane with cyanoacrylate. Animals were sacrificed at 2 (n=4) and 8 weeks (n=5) for microcomputed tomography and histomorphometric analysis. DOPA showed low peel resistance but high cell viability.RESULT:
Cyanoacrylate and DOPA groups showed significantly higher mineralized tissue volume (MTV) compared to control and membrane groups at 2 weeks (P < 0.05). At 8 weeks, DOPA group showed the highest MTV. Significantly higher new bone area was found in DOPA group at 8 weeks (P < 0.05). Bone formation increased from 2 to 8 weeks in DOPA group (P < 0.05).CONCLUSION:
DOPA showed high cell viability and in vivo study revealed predictable performance in bone regeneration.Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Osteogenesis
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Skull
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Bone Regeneration
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Dihydroxyphenylalanine
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Cell Survival
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Adhesiveness
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Adhesives
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Collagen
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Cyanoacrylates
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X-Ray Microtomography
Пределы темы:
Animals
Язык:
En
Журнал:
Journal of Korean Dental Science
Год:
2018
Тип:
Article