The roles of activated protein C in experimental trauma models / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 311-315, 2018.
Article
в En
| WPRIM
| ID: wpr-771647
Ответственная библиотека:
WPRO
ABSTRACT
Trauma-induced coagulopathy is classified into primary and secondary coagulopathy, with the former elicited by trauma and traumatic shock itself and the latter being acquired coagulopathy induced by anemia, hypothermia, acidosis, and dilution. Primary coagulopathy consists of disseminated intravascular coagulation and acute coagulopathy of trauma shock (ACOTS). The pathophysiology of ACOTS is the suppression of thrombin generation and neutralization of plasminogen activator inhibitor-1 mediated by activated protein C that leads to hypocoagulation and hyperfibrinolysis in the circulation. This review tried to clarify the validity of activated protein C hypothesis that constitutes the main pathophysiology of the ACOTS in experimental trauma models.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Physiology
/
Wounds and Injuries
/
Blood Coagulation Disorders
/
Protein C
/
Thrombin
/
Acute Disease
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Plasminogen Activator Inhibitor 1
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Disease Models, Animal
/
Disseminated Intravascular Coagulation
Пределы темы:
Animals
/
Humans
Язык:
En
Журнал:
Chinese Journal of Traumatology
Год:
2018
Тип:
Article