Research Advances on the Pathogenesis of Primary Immune Thrombocytopenia--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1706-1710, 2019.
Article
в Zh
| WPRIM
| ID: wpr-775661
Ответственная библиотека:
WPRO
ABSTRACT
Abstract Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by less than 100×10/L platelet count in peripheral blood. The pathogenesis of ITP is complex and has not been fully elucidated. Currently, researches on the pathogenesis of ITP mainly focus on the disorders of humoral immunity and cellular immunity. In recent years, some new progress has been made in the study of this pathogenesis, including the platelet clearance pathway that is not dependent on Fc γ R mediation, the metalloproteinase (ADAM) 10 that can regulate T and B cells, and the abnormal expression of micro RNA in genetic factors. Under the joint action of multiple factors, the imbalance of the immune system in the body leads to the occurrence of ITP. This article reviews the research progress on humoral immunity, cellular immunity and other possible new pathogenesis of ITP in recent years.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Platelet Count
/
Blood Platelets
/
Purpura, Thrombocytopenic, Idiopathic
/
ADAM10 Protein
Тип исследования:
Etiology_studies
Пределы темы:
Humans
Язык:
Zh
Журнал:
Journal of Experimental Hematology
Год:
2019
Тип:
Article