Synthesis and anti-HBV activity evaluation of Matijin-Su derivatives containing gallic acid moiety / 药学学报
Acta Pharmaceutica Sinica
; (12): 1140-1145, 2017.
Article
в Zh
| WPRIM
| ID: wpr-779705
Ответственная библиотека:
WPRO
ABSTRACT
In this study, eleven containing gallic acid moiety derivatives of Matijin-Su(MTS)were synthesized and evaluated for their anti-HBV activities in HepG2 2.2.15 cells in an effort to find novel effective anti-hepatitis B virus(HBV)agents. Compounds 5c, 6c and 6d exhibited significant anti-HBV activity with IC50 values of 6.12, 8.44 and 9.86 μmol·L-1, respectively. Incorporation of gallic acid moiety into MTS derivatives can lead to profound changes in their anti-HBV activity, and could be worth of further research.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Acta Pharmaceutica Sinica
Год:
2017
Тип:
Article