Research progress of indoleamine 2,3-dioxygenase 1 in tumor immunotherapy / 药学学报
Acta Pharmaceutica Sinica
; (12): 1271-1278, 2018.
Article
в Zh
| WPRIM
| ID: wpr-779997
Ответственная библиотека:
WPRO
ABSTRACT
IDO1 (indoleamine 2,3-dioxygenase 1) is one of the most significant checkpoint in tumor immunology. Numerous studies indicates that IDO1 is abnormally expressed in breast cancer, colorectal cancer, liver cancer and other tumor tissues, participating in tumor immune escape through multiple pathways. This review is prepared to elucidate the biological function of IDO1, highlight its pivotal role in tumor evasion, and summarize IDO1 inhibitors in the clinical trials.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Acta Pharmaceutica Sinica
Год:
2018
Тип:
Article