Application value of NT-ProBNP and BNP in children with congenital heart disease / 国际儿科学杂志

ABSTRACT

Congenital heart disease (CHD) is the most common congenital malformation and also one of the common causes of heart failure in children.At present,the clinical diagnosis of heart failure in children mainly depends on the medical history,symptoms and signs,with strong subjectivity and lack of timely and simple objective criteria,which are easy to be missed.Brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-ProBNP) are polypeptides synthesized and secreted by ventricular myocytes,which have good sensitivity to reflect ventricular systolic,diastolic function and pre-and post-load.They have been widely used in various cardiovascular diseases.In recent years,many studies have shown that the plasma concentration of the two can be used to guide perioperative surgical treatment and evaluate the perioperative prognosis risk of children with CHD.This article reviews the application of BNP and NT-ProBNP in children with CHD with heart failure,especially during perioperative period.