Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 572-575, 2010.
Article
в Zh
| WPRIM
| ID: wpr-814416
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE@#To determine the role of fragile histidine triad (FHIT) and MDM2 in carcinogenesis of oral submucous fibrosis (OSF).@*METHODS@#The expression of FHIT and MDM2 was examined by immunohistochemical S-P method in 44 OSF cases, 15 canceration tissues of OSF, and 10 normal oral mucosa tissues.@*RESULTS@#The expression of FHIT was positive in the normal oral mucosa epithelium. The positive expression of FHIT decreased in the OSF and canceration tissues of the OSF.The rate of FHIT positive expression was significantly lower in canceration tissues of OSF than that of the OSF (P < 0.05). The expression of MDM2 was negative in normal oral mucosa epithelium. The positive expression of MDM2 increased in the OSF and canceration tissues of the OSF, and the rate of MDM2 positive expression was significantly higher in the canceration tissues of OSF than that of the OSF (P < 0.05).@*CONCLUSION@#The loss of FHIT and over-expression of MDM2 may play an important role in the carcinogenesis of OSF.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Oral Submucous Fibrosis
/
Mouth Neoplasms
/
Immunohistochemistry
/
Acid Anhydride Hydrolases
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Proto-Oncogene Proteins c-mdm2
/
Genetics
/
Metabolism
/
Mouth Mucosa
/
Neoplasm Proteins
Пределы темы:
Female
/
Humans
/
Male
Язык:
Zh
Журнал:
Journal of Central South University(Medical Sciences)
Год:
2010
Тип:
Article