Expression of PTEN, p53 and EGFR in the molecular subtypes of breast carcinoma and
the correlation among them / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 973-978, 2015.
Article
в Zh
| WPRIM
| ID: wpr-815240
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE@#To study the expression of PTEN, p53 and epidermal growth factor receptor (EGFR) in the molecular subtypes of breast carcinoma and to evaluate the correlations with triple-negative breast cancer.
@*METHODS@#Immunohistochemical MaxVision(TM) method was used to detect the expression of PTEN, p53, EGFR, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) in 291 cases of infiltrating ductal carcinoma of breast.
@*RESULTS@#The positive expression of PTEN, p53 and EGFR protein in breast carcinoma was 57.0%, 57.0% and 38.5%, respectively, which were significantly different from those in benign breast diseases (P<0.05). The expression of PTEN or EGFR in breast cancer was correlated with tumor size, histological grade, lymph node metastasis, TNM stage, ER and HER2 status (P<0.05); the expression of p53 was correlated with tumor size, histological grade and ER status (P<0.05). The difference of positive expression rates of PTEN, p53 and EGFR protein among different subtypes including luminal A, luminal B (HER2-), luminal B (HER2+), HER2 over-expression and triple-negative was statistically significant (P<0.05). There were close correlations among PTEN, p53 and EGFR in the triple-negative subtype (P<0.05).
@*CONCLUSION@#Low expression of PTEN and high expression of EGFR and p53 are observed in triple-negative breast cancer, which may synergistically contribute to the pathogenesis of triple-negative breast cancer.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Pathology
/
Breast Neoplasms
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Tumor Suppressor Protein p53
/
Classification
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Carcinoma, Ductal, Breast
/
Receptor, ErbB-2
/
PTEN Phosphohydrolase
/
Triple Negative Breast Neoplasms
Пределы темы:
Female
/
Humans
Язык:
Zh
Журнал:
Journal of Central South University(Medical Sciences)
Год:
2015
Тип:
Article