Effect of glucose metabolism on hypothalamus-pituitary-thyroid axis / 医学研究生学报

ABSTRACT

Glucose is the basic metabolic substrate and main source of energy for the body. A complex neuroendocrine system regulate blood glucose concertration to keep it at a constant level. Thyroid hormones participate in the regulation of glucose metabolism through the PI3K/ERK and other signaling pathways. At the same time, abnormal glucose metabolism can cause the abnormal regulation of hypothalamus pituitary thyroid axis. In this paper, we review the change and molecular mechanism of thyroid hormone, thyroid stimulating hormone and thyroid releasing hormone in Hypoglycemia and Hyperglycemia.