Clinical effect of surgery combined with chemotherapy and radiotherapy in children with central primitive neuroectodermal tumor and prognostic analysis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 589-594, 2020.
Article
в Zh
| WPRIM
| ID: wpr-828701
Ответственная библиотека:
WPRO
ABSTRACT
OBJCTIVE@#To study the clinical effect of surgery combined with chemotherapy and radiotherapy in children with central primitive neuroectodermal tumor (cPNET), as well as the risks factors for poor prognosis.@*METHODS@#A retrospective analysis was performed for the clinical data of 42 children who were diagnosed with cPNET from June 2012 to September 2018.@*RESULTS@#The 42 children had a median overall survival (OS) time of 2.0 years and a median event-free survival (EFS) time of 1.3 years; the 1-, 3-, and 5-year OS rates were 76.2%±6.6%, 41.4%±8.7%, 37.3%±8.8% respectively, and the 1-, 3-, and 5-year EFS rates were 64.3%±7.4%, 32.7%±8.0%, 28.0%±8.1% respectively. The univariate analysis showed that there were significant differences in the OS and EFS rates among the children with different patterns of surgical resection, chemotherapy cycles, and risk grades (P<0.05), and there was also a significant difference in the OS rate between the children receiving radiotherapy and those not receiving radiotherapy (P<0.05). The multivariate Cox regression analysis showed that chemotherapy cycles and risk grade were independent influencing factors for EFS and OS rates (P<0.05). The EFS and OS rates increased with the increase in chemotherapy cycles and the reduction in risk grade.@*CONCLUSIONS@#Multimodality therapy with surgery, chemotherapy, and radiotherapy is an effective method for the treatment of cPNET in children. Early diagnosis and treatment and adherence to chemotherapy for as long as possible may improve EFS and OS rates.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Prognosis
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
/
Neuroectodermal Tumors, Primitive
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Combined Modality Therapy
/
Disease-Free Survival
Тип исследования:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
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Screening_studies
Пределы темы:
Child
/
Humans
Язык:
Zh
Журнал:
Chinese Journal of Contemporary Pediatrics
Год:
2020
Тип:
Article