Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 295-305, 2020.
Article
в En
| WPRIM
| ID: wpr-829012
Ответственная библиотека:
WPRO
ABSTRACT
Objective@#Interferon-induced transmembrane protein 3 (IFITM3) is an important member of the IFITM family. However, the molecular mechanisms underlying its antiviral action have not been completely elucidated. Recent studies on IFITM3, particularly those focused on innate antiviral defense mechanisms, have shown that IFITM3 affects the body's adaptive immune response. The aim of this study was to determine the contribution of IFITM3 proteins to immune control of influenza infection .@*Methods@#We performed proteomics, flow cytometry, and immunohistochemistry analysis and used bioinformatics tools to systematically compare and analyze the differences in natural killer (NK) cell numbers, their activation, and their immune function in the lungs of -/- and wild-type mice.@*Results@#-/- mice developed more severe inflammation and apoptotic responses compared to wild-type mice. Moreover, the NK cell activation was higher in the lungs of -/- mice during acute influenza infection.@*Conclusions@#Based on our results, we speculate that the NK cells are more readily activated in the absence of IFITM3, increasing mortality in -/- mice.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Rodent Diseases
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Virology
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Acute Disease
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Orthomyxoviridae Infections
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Disease Models, Animal
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Influenza, Human
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Genetics
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Membrane Proteins
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Metabolism
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Mice, Inbred C57BL
Тип исследования:
Etiology_studies
Пределы темы:
Animals
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Female
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Humans
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Male
Язык:
En
Журнал:
Biomedical and Environmental Sciences
Год:
2020
Тип:
Article