Antinociceptive Interactions between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test
Journal of Korean Medical Science
; : 307-312, 2005.
Article
в En
| WPRIM
| ID: wpr-84035
Ответственная библиотека:
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ABSTRACT
Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting acute nociception. The authors evaluated the effects of intrathecal gabapentin, NMDA antagonist (MK801) and AMPA antagonist (NBQX) in the formalin test which shows injury-induced hyperalgesia as well as acute pain. We further assessed the interactions between gabapentin and either MK801 or NBQX. Male Sprague-Dawley rats were implanted with intrathecal catheters. To evoke pain, 50 microliter of 5% formalin solution was injected into the hindpaw. The interaction was investigated by a fixed dose analysis or an isobolographic analysis. MK801 and NBQX suppressed flinching responses during phase 1 of the formalin test, while gabapentin had little effect on phase 1. All three agents decreased the phase 2 flinching response. A fixed dose analysis in phase 1 showed that gabapentin potentiated the antinociceptive effect of MK801 and NBQX. Isobolographic analysis in phase 2 revealed a synergistic interaction after coadministration of gabapentin-MK801 or gabapentin-NBQX. Correspondingly, spinal gabapentin with NMDA or AMPA antagonist may be useful in managing acute pain and injury-induced hyperalgesia.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Quinoxalines
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Injections, Spinal
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Dizocilpine Maleate
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Rats, Sprague-Dawley
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Receptors, N-Methyl-D-Aspartate
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Receptors, AMPA
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Excitatory Amino Acid Antagonists
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Cyclohexanecarboxylic Acids
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Drug Interactions
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Gamma-Aminobutyric Acid
Пределы темы:
Animals
Язык:
En
Журнал:
Journal of Korean Medical Science
Год:
2005
Тип:
Article