Action mechanism of Jiangzhi Ligan Decoction in treatment of non-alcoholic fatty liver disease based on network pharmacology / 中草药

ABSTRACT

Objective: To characterize the “multi-components, multi-targets, and multi-pathways” mechanism of Jiangzhi Ligan Decoction on non-alcoholic fatty liver disease (NAFLD) using network pharmacology technology. Methods: Data regarding natural molecules of Jiangzhi Ligan Decoction, targets of NAFLD, and interactions between natural molecules and NAFLD targets were screened. Network pharmacology of the interactions between natural molecules and NAFLD targets were established using Cytoscape software. The biological process and the signaling pathway of the putative targets were analyzed using ClueGO. Results: The network analysis indicated that 82 active ingredients and 53 NAFLD related targets were screened in Jiangzhi Ligan Decoction, which was involved in regulation of insulin resistance, oxidative stress, inflammation, PI3K/Akt signaling pathway, inflammasome signaling pathway, IL-10 signaling pathway, and T cell signaling pathway. Conclusion: This study provides an important basis for further study on the pharmacological mechanism of Jiangzhi Ligan Decoction in the treatment of non-alcoholic fatty liver disease.