Analysis of central lymph node metastasis factors in papillary thyroid microcarcinoma with Hashimoto thyroiditis / 国际外科学杂志

ABSTRACT

Objective:To investigate the risk factors of central lymph node metastasis for thyroid microcarcinoma (PTMC) combined with Hashimoto thyroiditis (HT).Methods:A total of 572 patients with PTMC were admitted to the Thyroid Surgery Department of the First Affiliated Hospital of Zhengzhou University from January to December 2018. Their all pathological features were retrospectively analyzed. A total of 140 PTMC patients combined with HT were screened. The software of SPSS 23.0 was used to analyze risk factors related to lymph node metastasis in central region, which included gender, age, tumor size, number of lesions, mutated BRAFV600 E gene, external invasion. Results:Single factor analysis of these 140 patients showed, tumor size 6 mm or higher ( χ2=5.376, P=0.020), multifocal ( χ2=7.986, P=0.005), BRAFV600 E mutation positive ( χ2=5.072, P=0.024) and external invasion ( χ2=7.778, P=0.005) were statistically significant ( P<0.05). Multivariate logistic regression analysis showned, multifocal ( OR=2.473, P=0.018) and external invasion ( OR=3.608, P=0.048) were independent risk factors for lymph node metastasis in central region of patients who had PTMC combined with HT. Conclusion:In patients who have PTMC combined with HT, the risk of central lymph node metastasis increased when patients had multifocal or external invasion before surgery, at this time, preventive central lymph node dissection was recommended.