Advances in genetics research in the pathogenesis of amyotrophic lateral sclerosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1483-1489, 2020.
Article
в En
| WPRIM
| ID: wpr-880611
Ответственная библиотека:
WPRO
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease affecting the upper and lower motor neurons. It is characterized by progressive muscle weakness, atrophy and ultimate death due to dysphagia and dyspnea. There are many causes of ALS, among which the genetic factors show great relevance. Imbalance of protein homeostasis in neurons, prion-like proliferation and propagation of abnormal proteins, mitochondrial dysfunction, glutamate mediated excitotoxicity, and intraneuronal substance transport disorders are recognized as the pathogenesis.The study on gene mutation related to pathogenesis will bridge the molecular and cellular research of ALS, which can deepen the understanding of the occurrence and development of ALS and the role of gene mutation in ALS, and provide new ideas and enlightenment for the treatment of ALS.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Proteins
/
Neurodegenerative Diseases
/
Amyotrophic Lateral Sclerosis
/
Motor Neurons
/
Mutation
Тип исследования:
Etiology_studies
Пределы темы:
Humans
Язык:
En
Журнал:
Journal of Central South University(Medical Sciences)
Год:
2020
Тип:
Article