Current advances in research of semaphorin 3A:a potential target for the treatment of nospecific low back pain / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 589-592, 2021.
Article
в Zh
| WPRIM
| ID: wpr-888320
Ответственная библиотека:
WPRO
ABSTRACT
Nonspecific low back pain is closely associated with afferent nerve ingrowth into degenerated IVDs and increasing the inflammatory response. Members of the class 3 semaphorins signal their response through two prominent receptors; the NRP (Neuropilin-1) and the Plexin A. Sema3A (Semaphorin3A) is primarily known for their role in modulating neuronal survival as well as neurite outgrowth and guidance via regulation of Sema3A-NRP-1-plexinA signal pathway. Also, sema3A is shown to be conductive to innervate the inner painful degenerated IVDs (Intervertebral discs). Furthermore, sema3A is thought to act as a barrier to endothelial cells survival and migration on vascular endothelial growth factor (VEGF) and inhibition of KLF5-induced (Krüppel-like factor 5) inflammatory mediators within degenerated IVDs. Therefore, Sema3A produce a new perspective of dual-action therapeutic agent for attenuating the regulator of innervation and angiogenesis into degenerated IVDs and inhibition of KLF5-induced inflammation.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Low Back Pain
/
Semaphorin-3A
/
Neuropilin-1
/
Endothelial Cells
/
Vascular Endothelial Growth Factor A
Тип исследования:
Guideline
Пределы темы:
Humans
Язык:
Zh
Журнал:
China Journal of Orthopaedics and Traumatology
Год:
2021
Тип:
Article