Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 528-535, 2021.
Article
в En
| WPRIM
| ID: wpr-888781
Ответственная библиотека:
WPRO
ABSTRACT
In this study, three new germacranolide sesquiterpenes (1-3), together with six related known analogues (4-9) were isolated from the whole plant of Carpesium cernuum. Their structures were established by a combination of extensive NMR spectroscopic analysis, HR-ESIMS data, and ECD calculations. The anti-leukemia activities of all compounds towards three cell lines (HEL, KG-1a, and K562) were evaluated in vitro. Compounds 1-3 exhibited moderate cytotoxicity with IC
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Drug Screening Assays, Antitumor
/
Asteraceae
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K562 Cells
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Sesquiterpenes, Germacrane
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Phytochemicals
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Antineoplastic Agents, Phytogenic
Пределы темы:
Humans
Язык:
En
Журнал:
Chinese Journal of Natural Medicines (English Ed.)
Год:
2021
Тип:
Article