Research progress of T-type calcium channel in cancer / 中国医师杂志
Journal of Chinese Physician
; (12): 1266-1269, 2021.
Article
в Zh
| WPRIM
| ID: wpr-909693
Ответственная библиотека:
WPRO
ABSTRACT
In most non-excited cells, voltage-gated T-type calcium channels present three properties of activation, inactivation and slow inactivation, thus contribute to cellular calcium signaling and membrane potential. By which T-type calcium channels play an important role in many cancer cellular processes such as cell proliferation, differentiation, apoptosis, invasion, and metastasis. Inhibiting T-type calcium channels by drugs or genetic tools can change the related cellular currents and the intracellular Ca 2+ , thereby regulating the biological tumorigenesis. This article reviews the electrophysiological of T-type calcium channels during tumor progression, aims to provide a scientific basis for the study and treatment in cancer.
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Journal of Chinese Physician
Год:
2021
Тип:
Article