Co-amorphous technology to improve dissolution and physical stability of silybin / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 103-110, 2022.
Article
в Zh
| WPRIM
| ID: wpr-927916
Ответственная библиотека:
WPRO
ABSTRACT
The present study explored the effect of co-amorphous technology in improving the dissolution rate and stability of silybin based on the puerarin-silybin co-amorphous system prepared by the spray-drying method. Solid-state characterization was carried out by powder X-ray diffraction(PXRD), polarizing microscopy(PLM), Fourier transform infrared spectroscopy(FT-IR), differential scanning calorimetry(DSC), etc. Saturated powder dissolution, intrinsic dissolution rate, moisture absorption, and stability were further investigated. The results showed that puerarin and silybin formed a co-amorphous system at a single glass transition temperature which was higher than that of any crude drug. The intrinsic dissolution rate and supersaturated powder dissolution of silybin in the co-amorphous system were higher than those of the crude drug and amorphous system. The co-amorphous system kept stable for as long as three months under the condition of 40 ℃, 75% relative humidity, which was longer than that of the single amorphous silybin. Therefore, the co-amorphous technology could significantly improve the dissolution and stability of silybin.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Silymarin
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Solubility
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Technology
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X-Ray Diffraction
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Calorimetry, Differential Scanning
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Spectroscopy, Fourier Transform Infrared
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Desiccation
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Drug Compounding
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Drug Stability
Язык:
Zh
Журнал:
China Journal of Chinese Materia Medica
Год:
2022
Тип:
Article