The effects of heroin on intracellular free Ca2+ of rat myocardium / 法医学杂志
Journal of Forensic Medicine
; (6): 424-427, 2007.
Article
в Zh
| WPRIM
| ID: wpr-983331
Ответственная библиотека:
WPRO
ABSTRACT
OBJECTIVE@#To observe the effects of heroin on intracellular free Ca2+ in rat myocardium.@*METHODS@#The effects of heroin on intracellular free Ca2+ were observed in cultured neonatal rat myocardium by measuring intracellular free Ca2+ concentration using calcium fluorescent probe Flou-3/AM and laser scanning confocal microscope.@*RESULTS@#Different doses and concentrations of heroin appeared to have different effects on intracellular free Ca2+ concentrations, with a dosage dependent short linear increase in the fluorescence intensity (i.e., Ca2+ concentration) leading to [Ca2+]i peak.@*CONCLUSION@#Heroin could affect concentrations of [Ca2+]i in myocardium and its dosage related effect needs further investigation.
Полный текст:
1
База данных:
WPRIM
Основная тема:
Cells, Cultured
/
Calcium
/
Rats, Sprague-Dawley
/
Microscopy, Confocal
/
Calcium Signaling
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Myocytes, Cardiac
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Heroin
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Dose-Response Relationship, Drug
/
Microscopy, Fluorescence
Пределы темы:
Animals
Язык:
Zh
Журнал:
Journal of Forensic Medicine
Год:
2007
Тип:
Article