Preoperative detection of TERT promoter and BRAFV600E mutations in papillary thyroid carcinoma in high-risk thyroid nodules
Arch. endocrinol. metab. (Online)
; 63(2): 107-112, Mar.-Apr. 2019. tab, graf
Article
在 En
| LILACS
| ID: biblio-1001216
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Objectives:
This observational study analyzed telomerase reverse transcriptase (pTERT) mutations in 45 fine-needle aspiration (FNA) specimens obtained from thyroid nodules followed by postoperatively confirmation of papillary thyroid cancer (PTC) diagnosis, examining their relationship with clinicopathologic aspects and the BRAFV600E mutation. Subjects andmethods:
Clinical information was collected from patients who presented to Ribeirao Preto University Hospital for surgical consultation regarding a thyroid nodule and who underwent molecular testing between January 2010 to October 2012. Tests included a DNA-based somatic detection of BRAFV600E and pTERT mutations.Results:
We found coexistence of pTERTC228T and BRAFV600E mutations in 8.9% (4/45) of thyroid nodules. All nodules positive for pTERT mutations were BRAFV600E positives. There was a significant association between pTERTC228T/BRAFV600E with older age and advanced stage compared with the group negative for either mutation.Conclusions:
This series provides evidence that FNA is a reliable method for preoperative diagnosis of high-risk thyroid nodules. pTERTC228T/BRAFV600E mutations could be a marker of poor prognosis. Its use as a personalized molecular medicine tool to individualize treatment decisions and follow-up design needs to be further studied.Key words
全文:
1
索引:
LILACS
主要主题:
Thyroid Neoplasms
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Thyroid Nodule
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Telomerase
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Proto-Oncogene Proteins B-raf
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Thyroid Cancer, Papillary
研究类型:
Diagnostic_studies
/
Etiology_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
限制:
Adolescent
/
Adult
/
Aged
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Female
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Humans
/
Male
语言:
En
期刊:
Arch. endocrinol. metab. (Online)
期刊主题:
ENDOCRINOLOGIA
/
METABOLISMO
年:
2019
类型:
Article