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Nasal polyposis: more than a chronic inflammatory disorder-a disease of mechanical dysfunction - the São paulo position
Pezato, Rogerio; Voegels, Richard Louis; Pignatari, Shirley; Gregório, Luiz Carlos; Bezerra, Thiago Freire Pinto; Gregorio, Luciano; Balsalobre, Leonardo; Tepedino, Miguel Soares; Coronel, Nathália; Pinna, Fabio de Rezende; Mendes Neto, José; Oliveira, Pedro; Macoto, Eduardo; Stefanini, Renato; Figueiredo, Claudia; Haddad, Fernanda; Pilan, Renata; Soter, Ana Bezerra; Melo, Nelson Almeida; Candido, Danilo Almeida; Amaral, Jonatas do; Santos, Rodrigo de Paula; Zele, Thibaut Van; Fujita, Reginaldo; Dreyfuss, Juliana L; Chamon, Wallace; Alencar, Adriano Mesquita; Perez-Novo, Claudina; Stamm, Aldo Cassol.
Affiliation
  • Pezato, Rogerio; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Voegels, Richard Louis; Department of Otolaryngology, USP. São Paulo. BR
  • Pignatari, Shirley; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Gregório, Luiz Carlos; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Bezerra, Thiago Freire Pinto; Department of Otolaryngology, UFPE. Recife. BR
  • Gregorio, Luciano; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Balsalobre, Leonardo; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Tepedino, Miguel Soares; Department of Otolaryngology, UERJ. Rio de Janeiro. BR
  • Coronel, Nathália; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Pinna, Fabio de Rezende; Department of Otolaryngology, USP. São Paulo. BR
  • Mendes Neto, José; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Oliveira, Pedro; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Macoto, Eduardo; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Stefanini, Renato; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Figueiredo, Claudia; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Haddad, Fernanda; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Pilan, Renata; Department of Otolaryngology, USP. São Paulo. BR
  • Soter, Ana Bezerra; Department of Otolaryngology, USP. São Paulo. BR
  • Melo, Nelson Almeida; Department of Otolaryngology, USP. São Paulo. BR
  • Candido, Danilo Almeida; Department of Medicine, Nephrology Division, Unifesp. São Paulo. BR
  • Amaral, Jonatas do; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Santos, Rodrigo de Paula; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Zele, Thibaut Van; Ear, Nose and Throat Department,, University of Ghent. Ghent. BE
  • Fujita, Reginaldo; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
  • Dreyfuss, Juliana L; Department of Biochemistry, Unifesp. São Paulo. BR
  • Chamon, Wallace; Department of Ophthalmology and Visual Sciences, Unifesp. Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago. São Paulo. BR
  • Alencar, Adriano Mesquita; Laboratory of Microrheology and Molecular Physiology, Institute of Physics, USP. São Paulo. BR
  • Perez-Novo, Claudina; Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp. Antuérpia. BE
  • Stamm, Aldo Cassol; Department of Otolaryngology - Head and Neck Surgery, Unifesp. São Paulo. BR
Int. arch. otorhinolaryngol. (Impr.) ; 23(2): 241-249, 2019. ilus, tab
Article 在 En | LILACS | ID: biblio-1015650
Responsible library: BR66.1
ABSTRACT

Introduction:

The importance of our study lies in the fact that we have demonstrated the occurrence ofmechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity.

Objective:

To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data Synthesis We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension.

Conclusion:

The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP (AU)
Subject(s)
Key words

全文: 1 索引: LILACS 主要主题: Nasal Polyps / Inflammation 限制: Humans 国家/地区名称主题: America do sul / Brasil 语言: En 期刊: Int. arch. otorhinolaryngol. (Impr.) 期刊主题: OTORRINOLARINGOLOGIA 年: 2019 类型: Article

全文: 1 索引: LILACS 主要主题: Nasal Polyps / Inflammation 限制: Humans 国家/地区名称主题: America do sul / Brasil 语言: En 期刊: Int. arch. otorhinolaryngol. (Impr.) 期刊主题: OTORRINOLARINGOLOGIA 年: 2019 类型: Article