Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 42(2): 128-135, Mar.-Apr. 2020. tab
Article
在 En
| LILACS
| ID: biblio-1089246
Responsible library:
BR1.1
ABSTRACT
Objective:
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.Methods:
Data from the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS) were used. Participants were antidepressant-free at baseline and presented with an acute, moderate-to-severe unipolar depressive episode. They were randomized to receive escitalopram/tDCS-sham (n=75), tDCS/placebo-pill (n=75), or placebo-pill/sham-tDCS (n=45). General linear models assessed the interaction between treatment group and allele-wise carriers. Additional analyses were performed for each group and each genotype separately.Results:
Pairwise group comparisons (tDCS vs. placebo, tDCS vs. escitalopram, and escitalopram vs. placebo) did not identify alleles associated with depression improvement. In addition, exploratory analyses also did not identify any SNP unequivocally associated with improvement of depression in any treatment group.Conclusion:
Larger, combined datasets are necessary to identify candidate genes for tDCS response.Key words
全文:
1
索引:
LILACS
主要主题:
Citalopram
/
Antidepressive Agents, Second-Generation
/
Depressive Disorder, Major
/
Transcranial Direct Current Stimulation
研究类型:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
限制:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
语言:
En
期刊:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
期刊主题:
PSIQUIATRIA
年:
2020
类型:
Article