Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly
Arch. endocrinol. metab. (Online)
; 64(4): 436-444, July-Aug. 2020. tab, graf
Article
在 En
| LILACS
| ID: biblio-1131103
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Objective Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone - PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Subjects and methods A cross-sectional study with 298 participants (46% men) in the São Paulo Health Survey 2014-2015. Spearman correlations were performed to evaluate the associations between vitamin K intake and the biochemical and body composition measures. Results Among normal-weight male adults (n = 15), PK intake presented a positive correlation with the quantitative insulin sensitivity check index (QUICKI) (r = 0.525; p = 0.045). Among men with high fat mass index (FMI) (n = 101), PK intake had a negative correlation with homeostasis model assessment estimate for β-cell function (HOMA-β) (r = −0.227; p = 0.022). In women with high FMI (n = 122), PK intake had a negative correlation with HOMA-β (r = −0.199, p = 0.032) and insulin (r = −0.207, p = 0.026). No correlations were found between PK intake and lipid profile. Conclusions Our findings support a potential relationship among PK intake, body fat and markers of glucose homeostasis in adults and the elderly.
Key words
全文:
1
索引:
LILACS
主要主题:
Insulin Resistance
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Diabetes Mellitus, Type 2
/
Homeostasis
研究类型:
Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
限制:
Adult
/
Aged
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Female
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Humans
/
Male
语言:
En
期刊:
Arch. endocrinol. metab. (Online)
期刊主题:
ENDOCRINOLOGIA
/
METABOLISMO
年:
2020
类型:
Article