Analysis of the endometrial transcriptome at the time of implantation in women receiving a single post-ovulatory dose of levonorgestrel or mifepristone
Rev. invest. clín
; 72(6): 363-371, Nov.-Dec. 2020. tab, graf
Article
在 En
| LILACS
| ID: biblio-1289731
Responsible library:
BR1.1
ABSTRACT
Abstract Background:
Levonorgestrel (LNG) is a progesterone receptor agonist used in both regular and emergency hormonal contraception; however, its effects on the endometrium as a contraceptive remain widely unknown and under public debate.Objective:
To analyze the effects of LNG or mifepristone (MFP), a progesterone receptor antagonist and also known as RU-486, administered at the time of follicle rupture (FR) on endometrial transcriptome during the receptive period of the menstrual cycle.Methods:
Ten volunteers ovulatory women were studied during two menstrual cycles, a control cycle and a consecutively treated cycle; in this last case, women were randomly allocated to two groups of 5 women each, receiving one dose of LNG (1.5 mg) or MFP (50 mg) the day of the FR by ultrasound. Endometrial biopsies were taken 6 days after drug administration and prepared for microarray analysis.Results:
Genomic functional analysis in the LNG-treated group showed as activated the bio-functions embryo implantation and decidualization, while these bio-functions in the T-MFP group were predicted as inhibited.Conclusions:
The administration of LNG as a hormonal emergency contraceptive resulted in an endometrial gene expression profile associated with receptivity. These results agree on the concept that LNG does not affect endometrial receptivity and/or embryo implantation when used as an emergency contraceptive.Key words
全文:
1
索引:
LILACS
主要主题:
Embryo Implantation
/
Mifepristone
/
Levonorgestrel
/
Contraceptives, Postcoital, Hormonal
/
Endometrium
/
Transcriptome
研究类型:
Clinical_trials
/
Prognostic_studies
限制:
Adult
/
Female
/
Humans
语言:
En
期刊:
Rev. invest. clín
期刊主题:
MEDICINA
年:
2020
类型:
Article