Assessment of liver disease by non-invasive methods in perinatally infected Brazilian adolescents and young adults living with Human Immunodeficiency Virus (HIV)
Braz. j. infect. dis
; Braz. j. infect. dis;25(3): 101589, 2021. tab
Article
在 En
| LILACS
| ID: biblio-1339425
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Introduction:
Effective and long-term combined antiretroviral therapy (cART) has decreased morbidity and mortality in HIV-infected individuals. Despite treatment advances, HIV-infected children continue to develop noninfectious conditions, including liver fibrosis.Methods:
Cross-sectional study designed to identify liver fibrosis in HIV-infected adolescents and young adults, in an outpatients clinic of Pediatric Infectious Diseases Division at Escola Paulista de Medicina/Universidade Federal de São Paulo (UNIFESP), diagnosed by noninvasive methods (liver elastography-FibroScan®, APRI and FIB4). Variables examined included demographics, clinical, laboratories, HIV treatment. All participants underwent FibroScan® to measure liver parenchyma elasticity. Values equal to above 7.0 kPa were interpreted as the presence of significant liver fibrosis. Two different biomarkers of liver fibrosis were employed the AST-to-Platelet Ratio Index (APRI) and the Fibrosis-4 score (FIB-4). APRI values above 1.5 have been considered as levels of clinically significant liver fibrosis and FIB-4 values above 3.25 suggested the presence of advanced fibrosis.Results:
Between August 2014 and March 2017, the study enrolled 97 patients, age 10-27 years old, fourteen of 97 subjects (14.4%) presented liver stiffness (≥7 kPa) detected by the liver elastography. No patient had APRI> 1.5. No patient had FIB4 value > 3.25. The only isolated laboratory parameter that could be significantly associated with high liver stiffness was thrombocytopenia (p= 0.022, Fisher's exact test).Conclusion:
Liver stiffness was identified in 14.4% (14/97) of this cohort by liver elastography. Liver disease in HIV-infected adolescents and young adults manifests itself silently, so should be routinely investigated.Key words
全文:
1
索引:
LILACS
主要主题:
HIV Infections
/
Liver
/
Liver Cirrhosis
研究类型:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
限制:
Adolescent
/
Adult
/
Child
/
Humans
国家/地区名称主题:
America do sul
/
Brasil
语言:
En
期刊:
Braz. j. infect. dis
期刊主题:
DOENCAS TRANSMISSIVEIS
年:
2021
类型:
Article