Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes
Braz. J. Pharm. Sci. (Online)
; 57: e18997, 2021. tab, graf
Article
在 En
| LILACS
| ID: biblio-1345455
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
In the present study a series of 34 synthetic ligustrazine-containing α, ß-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, ß-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasis
Key words
全文:
1
索引:
LILACS
主要主题:
Oximes
/
Cyclohexanones
语言:
En
期刊:
Braz. J. Pharm. Sci. (Online)
期刊主题:
Farmacologia
/
Teraputica
/
Toxicologia
年:
2021
类型:
Article