Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study
São Paulo med. j
; São Paulo med. j;140(3): 390-397, May-June 2022. tab, graf
Article
在 En
| LILACS
| ID: biblio-1377390
Responsible library:
BR1.1
ABSTRACT
ABSTRACT BACKGROUND:
Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction.OBJECTIVE:
Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN ANDSETTING:
Prospective study at a university hospital in Turkey.METHODS:
The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured.RESULTS:
No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group.CONCLUSION:
Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.Key words
全文:
1
索引:
LILACS
主要主题:
Diabetes, Gestational
研究类型:
Observational_studies
/
Risk_factors_studies
限制:
Animals
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Female
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Humans
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Pregnancy
语言:
En
期刊:
Sao Paulo Med J
/
São Paulo med. j
/
São Paulo med. j. (Online)
/
São Paulo medical journal (Impresso)
期刊主题:
Cirurgia Geral
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Cincia
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Ginecologia
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MEDICINA
/
Medicina Interna
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Obstetr¡cia
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Pediatria
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Sa£de Mental
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Sa£de P£blica
年:
2022
类型:
Article