Naringin is a promising natural compound for therapy of iron-overload disorders
Braz. J. Pharm. Sci. (Online)
; 58: e19409, 2022. graf
Article
在 En
| LILACS
| ID: biblio-1383963
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl's staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders
Key words
全文:
1
索引:
LILACS
主要主题:
Iron Overload
/
Flavanones
限制:
Animals
语言:
En
期刊:
Braz. J. Pharm. Sci. (Online)
期刊主题:
Farmacologia
/
Teraputica
/
Toxicologia
年:
2022
类型:
Article