Frequency of the DI*A, DI*B and Band 3 Memphis polymorphism among distinct groups in Brazil
Hematol., Transfus. Cell Ther. (Impr.)
; 45(supl.2): S91-S94, July 2023. tab, graf
Article
在 En
| LILACS
| ID: biblio-1514206
Responsible library:
BR408.1
Localization: BR408.1
ABSTRACT
ABSTRACT Introduction:
The Band 3 is a red blood cell protein that carries the Dia and Dib antigens from the Diego blood system. The SLC4A1 gene encodes Band 3; Band 3 Memphis is a polymorphism of normal Band 3 and has two variants, but only the variant II carries the Dia antigen.Objectives:
Describe the frequencies of the DI*A and DI*B alleles and the Band 3 Memphis among blood donors, sickle cell disease (SCD) patients and Amazonian Indians.Methods:
A total of 427 blood samples were collected and separated into three groups 206 unrelated blood donors, 90 patients with SCD and 131 Amazonian Indians. We performed DI*A/B, normal Band 3 and Band 3 Memphis genotyping, using the Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP).Results:
The frequency of the DI*A/DI*A genotype was 0.5% in blood donors and it was not found in other groups. The frequency of the DI*A/DI*B was higher in Amazonian Indians (33.6%) and the frequency of the DI*B/DI*B was highest in blood donors (92.2%). All 105 individuals tested were positive for the presence of normal Band 3 and of these individuals, only 5/105 (4.8%) presented the Band 3 Memphis mutation.Conclusion:
We observed a higher frequency of the DI*B allele in blood donors and a low frequency of the DI*A/DI*A genotype in all groups studied. The Band 3 Memphis was found in a higher frequency in the blood donor group. Our findings highlight the importance of analyzing different population groups to gain a better understanding of the genetic association of blood group antigens.Key words
全文:
1
索引:
LILACS
主要主题:
Anemia, Sickle Cell
限制:
Humans
国家/地区名称主题:
America do sul
/
Brasil
语言:
En
期刊:
Hematol Transfus Cell Ther
/
Hematol., Transfus. Cell Ther. (Impr.)
/
Hematology, Transfusion and Cell Therapy (Impresso)
/
Hematology, Transfusion and Cell Therapy (Online)
期刊主题:
Hematologia
/
TransfusÆo de Sangue
年:
2023
类型:
Article