ABSTRACT
Abstract
Objective:
To determine whether peripheral
blood parameters have any predictive value for all-frequency Sudden
Sensorineural Hearing Loss (SSNHL).
Methods:
We chose 78 individuals with all-frequency SSNHL
who had been admitted to our department. They were divided into two groups the effective group and the ineffective group. In
patients with all-frequency SSNHL, the prognostic variables, including peripheral
blood tests and clinical traits, were examined by a
logistic regression analysis. In addition, the predictive value was carried out.
Results:
The effective rate of all-frequency SSNHL was 61.5%. Pre-
treatment hearing level and the proportion of
patients with diabetes were both significantly lower in the effective group than in the ineffective group (p = 0.024 and 0.000, respectively). The levels of
fibrinogen and
C-reactive protein were also significantly different between the two groups (p = 0.001 and 0.025, respectively). Pre-
treatment hearing level and
fibrinogen level both significantly impacted the
prognosis of all-frequency SSNHL (p = 0.032 and 0.002, respectively), according to a
logistic regression analysis. Furthermore, the
prognosis was significantly predicted by both
fibrinogen level and pre-
treatment hearing level (p = 0.001 and 0.0002, respectively). The
receiver operating characteristic curve showed that the
fibrinogen level had a
sensitivity of 85.4% and a
specificity of 60.0% for predicting the
prognosis of all-frequency SSNHL.
Conclusion:
For the
prognosis of all-frequency SSNHL, the
fibrinogen level can be regarded as a useful predictor. The level of
C-reactive protein, however, does not have a significant prognostic effect on predicting all-frequency SSNHL. Therefore, more
attention should be devoted to the level of
fibrinogen in the acute period of all-frequency SSNHL. Level of Evidence 4.