Alta prevalencia de dislipidemias y riesgo aterogénico en una población infanto-juvenil / High prevalence of dyslipidemia and high atherogenic index of plasma in children and adolescents
Rev. méd. Chile
; 146(10): 1112-1122, dic. 2018. tab, graf
Article
在 Es
| LILACS
| ID: biblio-978746
Responsible library:
CL1.1
ABSTRACT
Background:
Dyslipidemias in childhood increase the risk of cardiovascular events in adult life.Aim:
To evaluate the prevalence of dyslipidemia and risk of atherogenicity based in the atherogenic index of plasma (AIP) in a sample of school children and adolescents. Material andMethods:
Cross-sectional study of 208 children aged 10.4 ± 1.0 years (107 women). Demographic data were obtained, and a clinical evaluation was conducted, including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure total cholesterol (CT), HDL cholesterol (cHDL) and triglycerides (TG), glucose and insulin. LDL cholesterol (cLDL), Non-HDL cholesterol and the indices CT/cHDL, cLDL/cHDL and AIP (log[TG/cHDL]) were calculated. Risk categories according to AIP for the pediatric population were also determined (low AIP < 0.11, intermediate AIP 0.11-0.21, high AIP > 0.21).Results:
Thirty eight percent of participants had dyslipidemia, without differences by gender and pubertal development. The frequency of dyslipidemia was significantly higher in children with obesity (54%, p < 0.01) and a waist circumference over percentile 90 (61%; p < 0.01). The later conditions had also higher CT/cHDL, cLDL/cHDL and AIP. According to AIP, 54% of children had a high atherogenicity risk along with alterations in anthropometric parameters and insulin resistance. All anthropometric and insulin resistance parameters were significantly correlated with the AIP.Conclusions:
There is a high prevalence of dyslipidemia in the studied population, which is associated with an increased cardiometabolic risk. The indices of atherogenicity and particularly AIP are correlated with nutritional status, abdominal obesity and parameters of insulin resistance.Key words
全文:
1
索引:
LILACS
主要主题:
Triglycerides
/
Cholesterol
/
Dyslipidemias
研究类型:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
限制:
Child
/
Female
/
Humans
/
Male
国家/地区名称主题:
America do sul
/
Chile
语言:
Es
期刊:
Rev. méd. Chile
期刊主题:
MEDICINA
年:
2018
类型:
Article