IJFS-International Journal of Fertility and Sterility. 2015; 9 (3): 268-276
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| IMEMR
| ID: emr-174141
Responsible library:
EMRO
ABSTRACT
Until 2000 it was believed that gonadotropin-releasing hormone [GnRH] was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonado-tropin inhibitory hormone [GnlH] initiated a revolution in the field of reproductive physiology. Identification of GnlH homologues in mammals, the arginine-pheny-lalanine-amide [RFamide]-related peptides [RFRPs], indicated a similar function. Subsequently, further works conducted in various laboratories worldwide have shown that these neuropeptides inhibit the hypothalamic-hypophyseal axis. This review discusses the role of RFRPs in mammalian reproductive processes