IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis
Braz. j. infect. dis
; 15(2): 156-158, Mar.-Apr. 2011. ilus, tab
Article
在 En
| LILACS
| ID: lil-582425
Responsible library:
BR1.1
ABSTRACT
Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p < 0.05). CSF IL-8 levels were higher in ABM than in AM and controls (p < 0.05). Discriminatory power in ABM as assessed by the area under receiver operator (ROC) curve was 0.951 for IL-8, using a cut-off of 1.685 ng/dL (100 percent of sensitivity and 94 percent of specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal inflammation, IL-8 could be an important tool to differentiate ABM from AM.
Key words
全文:
1
索引:
LILACS
主要主题:
Meningitis, Bacterial
/
Meningitis, Aseptic
研究类型:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
限制:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
语言:
En
期刊:
Braz. j. infect. dis
期刊主题:
DOENCAS TRANSMISSIVEIS
年:
2011
类型:
Article