Critical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center.
Indian J Pathol Microbiol
; 2012 Jul-Sept 55(3): 294-302
Article
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| IMSEAR
| ID: sea-142256
ABSTRACT
Background:
De-differentiated liposarcomas (DDLSs) are uncommon tumors with a wide histopathological spectrum. Materials andMethods:
Over an 8-year period (2003-2011), 25 DDLSs, after review, were critically analyzed for histopathological features.Results:
Twenty-five tumors, in 14 men and 11 women (M F = 1.21), with age range of 22-88 years (mean, 53.9), occurred in retroperitoneum (14) (56%), thigh (3) (12%), paratesticular region (3) (12%), chest wall (2) (8%), leg (1) (4%), shoulder (1) (4%), and groin (1) (4%). Tumor size (21 tumors) varied from 7.5 to 25 cm (mean, 17.5). Histopathologically, DD component was high grade in 19 (76%) and low grade in 6 (24%) tumors. Whereas the most common WD component was adipocytic type; the most common DD component was pleomorphic sarcomatous (13) (52%), followed by myxofibrosarcomatous (MFS)-type (6) (24%). Low-grade DD components included MFS (2), fibrosarcoma (2), myogenic/myofibroblastic type (1), and IMFT-type (1). Three tumors displayed meningothelial-like whorls and metaplastic bone formation. Heterologous elements, noted in 11 (44%) tumors, included bone (8) and rhabdomyoblastic differentiation (2). Two tumors displayed homologous differentiation, reinforced with MDM2 staining. S100-P was diffusely positive in WD components (5/7) and focally in DD components (2/9). All patients were treated with surgery, including 10, who underwent adjuvant radiotherapy. Outcomes (16 patients, 64%), over 1-48 months included 10 patients free of disease, 4 died of disease, and 2 patients alive with disease.Conclusions:
This study forms the largest documentation of DDLSs, including its wide histopathological spectrum, from our country. Rare cases overlap with pleomorphic liposarcoma. S100-P and MDM2 are useful in substantiating adipocytic differentiation, especially in selected cases. Analysis of adequate tumor sections is vital for correct identification of a DDLS. Surgical excision with adjuvant RT forms optimal treatment.Key words
全文:
1
索引:
IMSEAR
主要主题:
Aged, 80 and over
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Aged
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Female
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Humans
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Male
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Immunohistochemistry
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S100 Proteins
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Adult
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Diagnosis, Differential
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Proto-Oncogene Proteins c-mdm2
研究类型:
Diagnostic_studies
/
Prognostic_studies
限制:
Aged80
国家/地区名称主题:
Asia
语言:
En
期刊:
Indian J Pathol Microbiol
年:
2012
类型:
Article