ABSTRACT
Background:
Fixed
drug eruption is a common cutaneous
adverse drug reaction which is characterised by sharply demarcated
skin lesions with
recurrences at the same site with each subsequent exposure to the culprit
drug. The causative
drugs for fixed
drug eruption (FDE) in any
population changes depend on many factors. The
knowledge of peculiar clinical features of FDE helps the treating
physician to recognise at early stage and avoidance of mismanagement of such cases. Material and
method:
In this context, we did a descriptive-analytical study of
patients who were diagnosed with FDE in single center between Feb 2013 to Sep 2017 from central
India.
Results:
Ninety seven
patients who developed FDE were studied in the study with 65%
males and 35%
females. Mean age at presentation in
males and
females were 34.95±16.90 and 37.12±12.98 years, respectively. Multiple lesions were present in 80.4% of
patients. Seventy four percent of
patients gave the
history of prior episodes. In 68%
patients, symptoms started and lesions developed within <24 hours of the
drug exposure. Mucosal lesions were seen in 46.4% and
skin lesions (non-mucosal) were seen in 36.1% and in
rest 17.5%
patients both mucosal and
skin lesions were present.
Antibiotics and
NSAIDS were the most common group of medications to cause FDE. Thirty two percent of
patients were caused by Fixed
Dose Combinations of
antibiotics and anti-protozoals.
Conclusion:
In conclusion, FDE is a common acute cutaneous
drug eruption that if not diagnosed timely leads not only to
recurrences but also causes apprehension and
morbidity.