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Case report on two diabetic donor eyes with no retinopathy: Clinicopathological and molecular studies
Indian J Ophthalmol ; 2019 Oct; 67(10): 1762-1765
Article | IMSEAR | ID: sea-197594
We were intrigued to analyze donor eyes of two individuals without retinopathy even after 40 years of type 2 diabetes mellitus. Targeted molecular factors associated with angiogenesis and the key antioxidant enzymes in retinal tissue were analyzed. Accordingly PEDF, Adiponectin and Paraoxonase 2 showed augmented mRNA expression in both the retina with no significant change in VEGF expression. Vitreous showed increased PEDF protein in donor 1 and Adiponectin in donor 2 with no change in VEGF protein. This study highlights the profile of specific molecular factors that contribute to the non-development of diabetic retinopathy changes in these individuals.
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全文: 1 索引: IMSEAR 期刊: Indian J Ophthalmol 年: 2019 类型: Article
全文: 1 索引: IMSEAR 期刊: Indian J Ophthalmol 年: 2019 类型: Article