Effect of Exendin-4 on endothelial progenitor cell function and AKT/eNOS signaling pathway in a mouse model of type 1 diabetes / 中国药理学通报

ABSTRACT

Aim To investigate the effect of Exendin4 on proliferation, migration, adhesion and senescence of endothelial progenitor cells (EPCs) in type I diabetic mice and its possible mechanism. Methods EPCs from 6-month diabetic mice were isolated and cultured by density gradient centrifugation. Cells were treated with different concentrations of Exendin-4 (1, 5, 10, 25 μmol · L