ABSTRACT
Objective:
Migraine and
tremor share some genetic
mutation sites,and clinical studies have also confirmed their correlation.This study aims to explore the clinical and electrophysiological characteristics of
migraine patients with concomitant
tremor,and to analyze the relevant influential factors of
tremor occurrence.
Methods:
We retrospectively analyzed the clinical data of 217
migraine patients who visited the Third Affiliated
Hospital of Qiqihar Medical
University from June 2022 to October 2023.The Clinical Rating Scale for
Tremor(CRST),Numerical Rating Scale(NRS),Generalized
Anxiety Disorder-7(
GAD-7),and Patient Health Questionnaire-9(
PHQ-9)were respectively used to assess the
tremor symptoms,degree of
headache,
anxiety,and
depression of
patients.All
patients underwent routine
head MR scanning and
electromyography examination,and were divided into a
migraine with
tremor group and a
migraine without
tremor group based on the
electromyogram examination.
Results:
The
migraine with
tremor group and the
migraine without
tremor group were included 52
patients(23.96%)and 165
patients(76.04%),respectively.Compared with the
migraine without
tremor group,the
migraine with
tremor group had a longer
course and duration of
headache,higher frequency of
headache attacks,higher NRS score,
GAD-7 score,and
PHQ-9 score,and fewer weekly
physical exercises.The differences were statistically significant(all P<0.05).There were no statistically significant differences in the presence or absence of prodromal
headache and
white matter hyperintensities(WMHs)between the 2 groups(both P>0.05).The evaluation results of the CRST showed that out of 217
migraine patients,39
patients(17.97%)were accompanied by tremors.The electromyographic results showed that all 52
migraine patients with tremors had
upper limb tremors,including 28
migraine patients with postural tremors and 24
migraine patients with static tremors.Compared with the
migraine patients with static tremors,the
migraine patients with postural tremors had lower average frequency,peak frequency,and
headache onset frequency(all P<0.05).Multiple
linear regression analysis showed that frequency of
physical exercise,duration of illness,frequency of
headache attacks,NRS score,
GAD-7 score,and
PHQ-9 score were
risk factors for
migraine patients with concomitant tremors(all P<0.05).
Conclusion:
Patients with
migraine mainly experience
upper limb postural tremors.Reduced
physical exercise,long
course of
disease,long duration of
headache,frequent
headache attacks,severe
headache,
anxiety,and
depression are
risk factors for
migraine patients with concomitant tremors.