ABSTRACT
BACKGROUND:
The application of orthodontic force triggers
autophagy in the periodontal
tissue via diverse signaling pathways,augmenting or attenuating the activity of relevant
cell types such as
periodontal ligament cells,
osteocytes,
osteoclasts,and
osteoblasts,thus facilitating the process of periodontal
remodeling.
OBJECTIVE:
To
review the
research progress in orthodontic force mediated
autophagy in periodontal
tissue and its impact on
orthodontic tooth movement.
METHODS:
The
PubMed,Web of
Science,
China Biology Medicine disc and CNKI were searched for
literature published from 2010 to 2023 to summarize the progress in
orthodontics-related
autophagy.And 76
papers were finally included in the
analysis and discussion. RESULTS AND
CONCLUSION:
Orthodontic force can trigger a series of biochemical signal changes through periodontal mechanical receptors and aseptic
inflammation they cause,leading to
autophagy in periodontal
tissue.Subsequently,
autophagy generates corresponding
feedback through cascaded amplified signaling pathways such as
Phosphoinositide 3-
kinase/
protein kinase B,Hippo,and
mitogen-activated protein kinase pathways,promoting periodontal
tissue remodeling and ultimately achieving
tooth movement and stability.Orthodontic force-induced
autophagy can differentially regulate
bone resorption on the
tooth pressure side and
bone formation on the tension side.Related targets have good prospects in the clinical application of orthodontic
treatment.
Orthodontics and
autophagy have complex mechanisms.However,existing
research has only focused on exploring the
role of
autophagy in
orthodontic tooth movement.Further exploration is needed to investigate the mutual regulatory effects between
autophagy and
orthodontic tooth movement,as well as the interactions between
upstream mechanical receptors and signaling pathways involved in related pathways.