ABSTRACT
Objective:
To explore the clinical and pathological characteristics and
prognostic factors of gastric
neuroendocrine carcinoma(G-NEC)and gastric mixed adenoendocrine
carcinoma(G-MANEC).
Methods:
Retrospective
analysis was conducted on the clinical data of 67
patients with G-NEC and G-MANEC
who underwent surgical
treatment at Heping
Hospital Affiliated to Changzhi Medical College from May 2015 to May 2023.The study included an
analysis of the pathological characteristics distinguishing G-NEC from G-MANEC.
Results:
Com-pared to gastric
adenocarcinoma,
patients with G-NEC and G-MANEC in the
stomach showed a higher
incidence of
gastric cancer in the
male gastric
cardia and were diagnosed at a later age.
Tumors with larger diameters increase susceptibility to
anemia,low
albumin levels,and in-vasion of nerves and vasculature.Deeper
tumor infiltration is associated with increased local
lymph node metastases,later
TNM staging,and a higher likelihood of distant
metastasis post-
surgery.The
prognosis of G-NEC and G-MANEC is worse than that of gastric
adenocarcinoma(P=0.001).However,there is no statistically significant difference in the pathological characteristics(P>0.05)and
prognosis analysis(P=0.212)between G-NEC and G-MANEC.Univariate
survival analysis identified age,preoperative
albumin,preoperative CEA,number of
lymph node metastases,
TNM staging,and postoperative distant
metastasis as
risk factors affecting
patient's overall
survival(OS).In the multivariate ana-lysis,age,preoperative
albumin,
TNM staging,and postoperative distant metastasiswere identified as independent
risk factors for OS.Con-clusionsThere is a significant difference in clinical characteristics between G-NEC,G-MANEC,and gastric
adenocarcinoma,often diagnosed at an advanced stage,which is prone to distant
metastasis post-
surgery.Poor
prognosis is observed in
patients aged over 60 years,with pre-operative
albumin<40g/L,TNM stage Ⅱ/Ⅲ,and postoperative distant
metastasis.
