Discussion on the autoimmune mechanism of epilepsy / 中华神经科杂志

ABSTRACT

Epilepsy arising from autoimmune etiologies has become increasingly prevalent in clinical practice. These cases typically exhibit limited responsiveness to conventional antiepileptic drugs, often progressing into drug-resistant epilepsy. Consequently, the early identification of autoimmune causes of epilepsy and the subsequent implementation of targeted immunotherapy are of paramount significance for clinicians. Presently, the pathogenesis of autoimmune epilepsy remains elusive, and standardized diagnostic and therapeutic guidelines are lacking. It is imperative that future endeavors involve extensive large-scale foundational research and clinical trials to delve deeper into the autoimmune mechanisms underpinning epilepsy.