ABSTRACT
Objective:
To summarize the clinical and neurophysiological characteristics of
epilepsy with blink inducing.
Methods:
The
patients with
epilepsy with blink test positive
who received 24 h-video-
electroencephalography (24 h-VEEG)
monitoring from May 2017 to May 2022 in the Xijing
Hospital, the
Air Force
Military Medical
University were enrolled. Their clinical and electrophysiological characteristics were studied and they were followed up to observe their
prognosis.
Results:
A total of 42
patients with
epilepsy with blink test positive were collected, 1 of whom was
lost to follow-up. The remaining 41
patients included 18
males (44%) and 23
females (56%), whose age was 3 to 12 (8.1±2.6) years.
Self-limited
epilepsy with centrotemporal spikes (SeLECTS) was diagnosed in 35
patients,
self-limited
epilepsy with autonomic seizures in 3, and developmental epileptic
encephalopathy with spike-and-
wave activation in
sleep in 3, respectively. The electrical
status epilepticus during
sleep (ESES) was found in 31
patients (76%), whereas 10 (24%) without ESES. Thirty-two
patients experienced 24 h-VEEG
monitoring more than twice, and 23 of them were seizure free, of whom blink inducing disappeared in 14
patients and existed in 9 in the last 24 h-VEEG
monitoring. Among the 9
patients who were not seizure free, blink inducing disappeared in 3
patients and remained in 6. There was no statistically significant difference between the two groups ( P>0.05). The age of the
patients whose blink inducing disappeared in the last 24 h-VEEG
monitoring after treatment was (11.3±3.1) years. Meanwhile the age of the
patients whose blink inducing remained was (9.1±2.3) years, and the difference between the two groups was statistically significant ( t=2.254, P=0.030).
Conclusions:
Blink inducing is highly age-dependent and common in
self-limited focal epilepsy and developmental epileptic
encephalopathy, especially in SeLECTS. Moreover,
patients with ESES are more likely to be blink test positive. There was no correlation between blink inducing and seizure outcome.