Different times and procedures of postoperative radiation and chemotherapy affecting treatment efficacy of high-grade gliomas / 中华神经医学杂志
Chinese Journal of Neuromedicine
; (12): 1143-1147, 2012.
Article
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| WPRIM
| ID: wpr-1033665
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ABSTRACT
Objective To investigate effects of different times and procedures of postoperative radiation and chemotherapy on treatment efficacy of high-grade gliomas.Methods A prospective clinical trial was conducted in 71 patients with high-grade gliomas (HGG); they were separated randomly into two groupsone group including 39 patients received chemo-radiotherapy and adjuvant chemotherapy sequentially (RC+C) and the other group including 32 patients received neo-adjuvant chemotherapy and chemo-radiotherapy and adjuvant chemotherapy sequentially (C+RC+C).The clinical benefit rate (CBP),progression free survival (PFS) and overall survival (OS) were followed up after the treatment.Results No significant difference on CBP 5 months after treatment was noted between the two groups (P>0.05),but the CBP in the C+RC+C group (87.5%) was significantly higher than that in the RC+C group (66.7%)8 months after treatment (P<0.05).No significant difference on OS was noted between the two groups.The median PFS of patients in C+RC+C group was 11.5 months while that in the RC+C group was 8.6 months; the PFS of patients in C+RC+C group was significantly longer that in the RC+C group (P<0.05).Conclusion Procedure of C+RC+C can prolong the PFS of patients with HGG.